Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome.
Identifieur interne : 000399 ( Main/Exploration ); précédent : 000398; suivant : 000400Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome.
Auteurs : Marco Armando [Suisse] ; Mariasole Ciampoli [Italie] ; Maria Carmela Padula [Suisse] ; Paul Amminger [Australie] ; Franco De Crescenzo [Italie] ; Johanna Maeder [Suisse] ; Maude Schneider [Suisse] ; Marie Schaer [Suisse] ; Francesca Manag [Italie] ; Stephan Eliez [Suisse] ; Francesco Papaleo [Italie]Source :
- Neuropharmacology [ 1873-7064 ] ; 2020.
Abstract
Omega-3-polyunsaturated-fatty-acids were suggested against cognitive dysfunctions and conversion to psychosis. However, a recent multicenter trial found no effect in reducing conversion rates in individuals at risk of developing schizophrenia. Patients' genetic heterogeneity and the timing of treatment might influence omega-3 efficacy. Here, we addressed the impact of omega-3 early treatment in both mice and human subjects with a 22q11.2 genetic hemi-deletion (22q11DS), characterized by cognitive dysfunctions and high penetrance of schizophrenia. We first tested the behavioural and cognitive consequences of adolescent exposure to normal or omega-3-enriched diets in wild-type and 22q11DS (LgDel/+) mice. We then contrasted mouse data with those gathered from sixty-two patients with 22q11DS exposed to a normal diet or supplemented with omega-3 during pre-adolescence/adolescence. Adolescent omega-3 exposure had no effects in wild-type mice. However, this treatment ameliorated distractibility deficits revealed in LgDel/+ mice by the Five Choice Serial Reaction Time Task (5CSRTT). The omega-3 improvement in LgDel/+ mice was selective, as no other generalized cognitive and non-cognitive effects were evident. Similarly, omega-3-exposed 22q11DS patients showed long-lasting improvements on distractibility as revealed by the continuous performance test (CPT). Moreover, omega-3-exposed 22q11DS patients showed less risk of developing an Ultra High Risk status and lower conversion rate to psychosis. Our convergent mouse-human findings represent a first analysis on the effects of omega-3 early treatment in 22q11DS. The beneficial effects in attentional control and transition to psychosis could support the early use of omega-3 supplementation in the 22q11DS population.
DOI: 10.1016/j.neuropharm.2020.107995
PubMed: 32057798
Affiliations:
- Australie, Italie, Suisse
- Canton de Genève, Latium
- Genève, Rome
- Université d'Oxford, Université de Genève
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Electronic address: marco.armando@unige.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Ciampoli, Mariasole" sort="Ciampoli, Mariasole" uniqKey="Ciampoli M" first="Mariasole" last="Ciampoli">Mariasole Ciampoli</name><affiliation wicri:level="1"><nlm:affiliation>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Padula, Maria Carmela" sort="Padula, Maria Carmela" uniqKey="Padula M" first="Maria Carmela" last="Padula">Maria Carmela Padula</name><affiliation wicri:level="4"><nlm:affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland; Friedrich Miescher Institute for Biomedical Research, 4058, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland; Friedrich Miescher Institute for Biomedical Research, 4058, Basel</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Amminger, Paul" sort="Amminger, Paul" uniqKey="Amminger P" first="Paul" last="Amminger">Paul Amminger</name><affiliation wicri:level="1"><nlm:affiliation>Orygen Youth Health Centre for Youth Mental Health, 35 Poplar Road, Parkville, VIC 3052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Orygen Youth Health Centre for Youth Mental Health, 35 Poplar Road, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="De Crescenzo, Franco" sort="De Crescenzo, Franco" uniqKey="De Crescenzo F" first="Franco" last="De Crescenzo">Franco De Crescenzo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, University of Oxford, Oxford, UK; Pediatric University Hospital-Department (DPUO), Bambino Gesù Children's Hospital, Rome, Italy; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Psychiatry, University of Oxford, Oxford, UK; Pediatric University Hospital-Department (DPUO), Bambino Gesù Children's Hospital, Rome, Italy; Department of Epidemiology, Lazio Regional Health Service, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Maeder, Johanna" sort="Maeder, Johanna" uniqKey="Maeder J" first="Johanna" last="Maeder">Johanna Maeder</name><affiliation wicri:level="4"><nlm:affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Schneider, Maude" sort="Schneider, Maude" uniqKey="Schneider M" first="Maude" last="Schneider">Maude Schneider</name><affiliation wicri:level="4"><nlm:affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Schaer, Marie" sort="Schaer, Marie" uniqKey="Schaer M" first="Marie" last="Schaer">Marie Schaer</name><affiliation wicri:level="4"><nlm:affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Manag, Francesca" sort="Manag, Francesca" uniqKey="Manag F" first="Francesca" last="Manag">Francesca Manag</name><affiliation wicri:level="1"><nlm:affiliation>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author><author><name sortKey="Eliez, Stephan" sort="Eliez, Stephan" uniqKey="Eliez S" first="Stephan" last="Eliez">Stephan Eliez</name><affiliation wicri:level="4"><nlm:affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author><author><name sortKey="Papaleo, Francesco" sort="Papaleo, Francesco" uniqKey="Papaleo F" first="Francesco" last="Papaleo">Francesco Papaleo</name><affiliation wicri:level="1"><nlm:affiliation>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova, Italy. Electronic address: francesco.papaleo@iit.it.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova</wicri:regionArea><wicri:noRegion>Genova</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neuropharmacology</title><idno type="eISSN">1873-7064</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Omega-3-polyunsaturated-fatty-acids were suggested against cognitive dysfunctions and conversion to psychosis. However, a recent multicenter trial found no effect in reducing conversion rates in individuals at risk of developing schizophrenia. Patients' genetic heterogeneity and the timing of treatment might influence omega-3 efficacy. Here, we addressed the impact of omega-3 early treatment in both mice and human subjects with a 22q11.2 genetic hemi-deletion (22q11DS), characterized by cognitive dysfunctions and high penetrance of schizophrenia. We first tested the behavioural and cognitive consequences of adolescent exposure to normal or omega-3-enriched diets in wild-type and 22q11DS (LgDel/+) mice. We then contrasted mouse data with those gathered from sixty-two patients with 22q11DS exposed to a normal diet or supplemented with omega-3 during pre-adolescence/adolescence. Adolescent omega-3 exposure had no effects in wild-type mice. However, this treatment ameliorated distractibility deficits revealed in LgDel/+ mice by the Five Choice Serial Reaction Time Task (5CSRTT). The omega-3 improvement in LgDel/+ mice was selective, as no other generalized cognitive and non-cognitive effects were evident. Similarly, omega-3-exposed 22q11DS patients showed long-lasting improvements on distractibility as revealed by the continuous performance test (CPT). Moreover, omega-3-exposed 22q11DS patients showed less risk of developing an Ultra High Risk status and lower conversion rate to psychosis. Our convergent mouse-human findings represent a first analysis on the effects of omega-3 early treatment in 22q11DS. The beneficial effects in attentional control and transition to psychosis could support the early use of omega-3 supplementation in the 22q11DS population.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32057798</PMID><DateRevised><Year>2020</Year><Month>07</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-7064</ISSN><JournalIssue CitedMedium="Internet"><Volume>168</Volume><PubDate><Year>2020</Year><Month>05</Month><Day>15</Day></PubDate></JournalIssue><Title>Neuropharmacology</Title><ISOAbbreviation>Neuropharmacology</ISOAbbreviation></Journal><ArticleTitle>Favorable effects of omega-3 polyunsaturated fatty acids in attentional control and conversion rate to psychosis in 22q11.2 deletion syndrome.</ArticleTitle><Pagination><MedlinePgn>107995</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0028-3908(20)30061-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuropharm.2020.107995</ELocationID><Abstract><AbstractText>Omega-3-polyunsaturated-fatty-acids were suggested against cognitive dysfunctions and conversion to psychosis. However, a recent multicenter trial found no effect in reducing conversion rates in individuals at risk of developing schizophrenia. Patients' genetic heterogeneity and the timing of treatment might influence omega-3 efficacy. Here, we addressed the impact of omega-3 early treatment in both mice and human subjects with a 22q11.2 genetic hemi-deletion (22q11DS), characterized by cognitive dysfunctions and high penetrance of schizophrenia. We first tested the behavioural and cognitive consequences of adolescent exposure to normal or omega-3-enriched diets in wild-type and 22q11DS (LgDel/+) mice. We then contrasted mouse data with those gathered from sixty-two patients with 22q11DS exposed to a normal diet or supplemented with omega-3 during pre-adolescence/adolescence. Adolescent omega-3 exposure had no effects in wild-type mice. However, this treatment ameliorated distractibility deficits revealed in LgDel/+ mice by the Five Choice Serial Reaction Time Task (5CSRTT). The omega-3 improvement in LgDel/+ mice was selective, as no other generalized cognitive and non-cognitive effects were evident. Similarly, omega-3-exposed 22q11DS patients showed long-lasting improvements on distractibility as revealed by the continuous performance test (CPT). Moreover, omega-3-exposed 22q11DS patients showed less risk of developing an Ultra High Risk status and lower conversion rate to psychosis. Our convergent mouse-human findings represent a first analysis on the effects of omega-3 early treatment in 22q11DS. The beneficial effects in attentional control and transition to psychosis could support the early use of omega-3 supplementation in the 22q11DS population.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Armando</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland. Electronic address: marco.armando@unige.ch.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ciampoli</LastName><ForeName>Mariasole</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Padula</LastName><ForeName>Maria Carmela</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland; Friedrich Miescher Institute for Biomedical Research, 4058, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amminger</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Orygen Youth Health Centre for Youth Mental Health, 35 Poplar Road, Parkville, VIC 3052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Crescenzo</LastName><ForeName>Franco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Oxford, Oxford, UK; Pediatric University Hospital-Department (DPUO), Bambino Gesù Children's Hospital, Rome, Italy; Department of Epidemiology, Lazio Regional Health Service, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maeder</LastName><ForeName>Johanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>Maude</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schaer</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Managò</LastName><ForeName>Francesca</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eliez</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Developmental Imaging and Psychopathology Lab, Department of Psychiatry, University of Geneva, 1202, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papaleo</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Genetics of Cognition Laboratory, Neuroscience Area, Istituto Italiano di Tecnologia, Via Morego, 30, 16163, Genova, Italy. Electronic address: francesco.papaleo@iit.it.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neuropharmacology</MedlineTA><NlmUniqueID>0236217</NlmUniqueID><ISSNLinking>0028-3908</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Adolescence</Keyword><Keyword MajorTopicYN="Y">Attention</Keyword><Keyword MajorTopicYN="Y">Distractibility</Keyword><Keyword MajorTopicYN="Y">LgDel/+ mutant mice</Keyword><Keyword MajorTopicYN="Y">Translational pharmacology</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare no competing financial interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>08</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>02</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32057798</ArticleId><ArticleId IdType="pii">S0028-3908(20)30061-7</ArticleId><ArticleId IdType="doi">10.1016/j.neuropharm.2020.107995</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Australie</li><li>Italie</li><li>Suisse</li></country><region><li>Canton de Genève</li><li>Latium</li></region><settlement><li>Genève</li><li>Rome</li></settlement><orgName><li>Université d'Oxford</li><li>Université de Genève</li></orgName></list><tree><country name="Suisse"><region name="Canton de Genève"><name sortKey="Armando, Marco" sort="Armando, Marco" uniqKey="Armando M" first="Marco" last="Armando">Marco Armando</name></region><name sortKey="Eliez, Stephan" sort="Eliez, Stephan" uniqKey="Eliez S" first="Stephan" last="Eliez">Stephan Eliez</name><name sortKey="Maeder, Johanna" sort="Maeder, Johanna" uniqKey="Maeder J" first="Johanna" last="Maeder">Johanna Maeder</name><name sortKey="Padula, Maria Carmela" sort="Padula, Maria Carmela" uniqKey="Padula M" first="Maria Carmela" last="Padula">Maria Carmela Padula</name><name sortKey="Schaer, Marie" sort="Schaer, Marie" uniqKey="Schaer M" first="Marie" last="Schaer">Marie Schaer</name><name sortKey="Schneider, Maude" sort="Schneider, Maude" uniqKey="Schneider M" first="Maude" last="Schneider">Maude Schneider</name></country><country name="Italie"><noRegion><name sortKey="Ciampoli, Mariasole" sort="Ciampoli, Mariasole" uniqKey="Ciampoli M" first="Mariasole" last="Ciampoli">Mariasole Ciampoli</name></noRegion><name sortKey="De Crescenzo, Franco" sort="De Crescenzo, Franco" uniqKey="De Crescenzo F" first="Franco" last="De Crescenzo">Franco De Crescenzo</name><name sortKey="Manag, Francesca" sort="Manag, Francesca" uniqKey="Manag F" first="Francesca" last="Manag">Francesca Manag</name><name sortKey="Papaleo, Francesco" sort="Papaleo, Francesco" uniqKey="Papaleo F" first="Francesco" last="Papaleo">Francesco Papaleo</name></country><country name="Australie"><noRegion><name sortKey="Amminger, Paul" sort="Amminger, Paul" uniqKey="Amminger P" first="Paul" last="Amminger">Paul Amminger</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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